Bioprocess Development / Contract Production
Fermentation process development from pilot to commercial-scale production
PROPHYTA provides the facilities and trained staff to develop, transfer, or scale up your solid-state fermentation process. PROPHYTA has developed a unique solid-state fermentation technology for production of filamentous fungi.
Out-source projects or increase capacity!
In the PROPHYTA-fermentation facilities we will optimize your production or develop a fermentation process that will improve the product’s performance – giving a competitive advantage on the market.
In addition to designing equipment and developing processes, PROPHYTA offers licences for its technology and expertise in solid-state fermentation technology.
Scale up
As the principle of the PROPHYTA®L-Fermenter and the PROPHYTA®fermenters of industrial size is the same, a scale up of an optimised bioprocess is always possible. PROPHYTA offers its expertise in production scale up, technology transfer and project management if a scale up is desired. After succeeding with the PROPHYTA®L-Fermenter the scale up usually begins with the medium sized PROPHYTA®Pilot Fermenter with external peripheral equipment (“pilot phase” of the scale up). In the final phase production will be set up on the desired commercial scale. The PROPHYTA®fermenters of industrial size can be licensed in order to build up a production unit. Alternatively it is possible to have the production done by PROPHYTA on commission.
Applications of Solid-State Fermentation
| Examples of suitable fungi | |
| Production of Biocontrol agents | |
| Fungicides | Coniothyrium minitans Trichoderma spp. |
| Herbicides | Colletorichum truncatum Phytophthora palmivora |
| Insecticides | Metarhizium anisopliae Verticillium lecanii Beauveria brongniartii |
| Nematicides | Peacilomyces lilacinus |
| Production of Enzymes | |
| CELLULASES, XYLANASE | Trichoderma spp. |
LIGNINASES
|
Phanerochaete chrysosporium Phanerochaete chrysosporium Pleurotus ostreatus, Trametes spp. |
PROTAESES
|
Rhizopus oligosporus |
| LIPASES | Penicillium condidum |
| GALCTOSIDASES AND PECTINASES | Aspergillus spp. |
| GLUTAMINASE | Pseudomonas fluorescens |
| AMYLASES | Aspergillus spp. |
| PHYTASE | Aspergillus spp. |
| INSULINASE | Aspergillus spp. |
| Production of Organic acids | |
| Citric Acid | Aspergillus niger |
| Lactic Acid | Rhizopus oryzae |
| Production of Secondary Metabolites | |
| Giberellic acid | Fusarium moniliforme |
| Ergot Alkaloids | Claviceps spp. |
| Antibiotics | depends on the antibiotic group |
| Cyclosporin | Tolypolcladium inflautum |
| Lovastatin | Aspergillus terreus |
| Taxol | Taxomyces andreanae |
| Production of Fungi Forming Ectomycorrhizae | |
| Pisolithus tinctorius | |
| Production of Mushroom Spawn | |
| Agaricus bisporus
Pleurotus ostreatus |
|
| Production of Fungal Inoculum | |
| Cheese production | Penicillium roquefortii Peniciliium camembertii |
| For resistance screening in plant breeding or fungicide testing | Sclerotinia spp. Fusarium spp. Typhula incarnata Pseudocercosporella spp. |
Advantages of PROPHYTA’s Solid-State Fermentation Technology
- Contamination-free growth conditions for long periods of time, which allows the production of even slow-growing fungi
- Microprocessor-controlled fermentation with data collection
- Cost effective
- High production capacity after scale up


