Bioprocess Development / Contract Production

Fermentation process development from pilot to commercial-scale production

PROPHYTA provides the facilities and trained staff to develop, transfer, or scale up your solid-state fermentation process. PROPHYTA has developed a unique solid-state fermentation technology for production of filamentous fungi.

Out-source projects or increase capacity!

In the PROPHYTA-fermentation facilities we will optimize your production or develop a fermentation process that will improve the product’s performance – giving a competitive advantage on the market.
In addition to designing equipment and developing processes, PROPHYTA offers licences for its technology and expertise in solid-state fermentation technology.

Scale up

As the principle of the PROPHYTA®L-Fermenter and the PROPHYTA®fermenters of industrial size is the same, a scale up of an optimised bioprocess is always possible. PROPHYTA offers its expertise in production scale up, technology transfer and project management if a scale up is desired. After succeeding with the PROPHYTA®L-Fermenter the scale up usually begins with the medium sized PROPHYTA®Pilot Fermenter with external peripheral equipment (“pilot phase” of the scale up). In the final phase production will be set up on the desired commercial scale. The PROPHYTA®fermenters of industrial size can be licensed in order to build up a production unit. Alternatively it is possible to have the production done by PROPHYTA on commission.

Applications of Solid-State Fermentation

Examples of suitable fungi
Production of Biocontrol agents
Fungicides Coniothyrium minitans
Trichoderma spp.
Herbicides Colletorichum truncatum
Phytophthora palmivora
Insecticides Metarhizium anisopliae
Verticillium lecanii

Beauveria brongniartii
Nematicides Peacilomyces lilacinus
Production of Enzymes
CELLULASES, XYLANASE Trichoderma spp.
LIGNINASES

  • Lignin peroxidase
  • Manganese peroxidase
  • Laccase
Phanerochaete chrysosporium
Phanerochaete chrysosporium
Pleurotus ostreatus, Trametes
spp.
PROTAESES

  • Proteolytic enzymes
Rhizopus oligosporus
LIPASES Penicillium condidum
GALCTOSIDASES AND PECTINASES Aspergillus spp.
GLUTAMINASE Pseudomonas fluorescens
AMYLASES Aspergillus spp.
PHYTASE Aspergillus spp.
INSULINASE Aspergillus spp.
Production of Organic acids
Citric Acid Aspergillus niger
Lactic Acid Rhizopus oryzae
Production of  Secondary Metabolites
Giberellic acid Fusarium moniliforme
Ergot Alkaloids Claviceps spp.
Antibiotics depends on the antibiotic group
Cyclosporin Tolypolcladium inflautum
Lovastatin Aspergillus terreus
Taxol Taxomyces andreanae
Production of Fungi Forming Ectomycorrhizae
Pisolithus tinctorius
Production of Mushroom Spawn
Agaricus bisporus

Pleurotus ostreatus

Production of Fungal Inoculum
Cheese production Penicillium roquefortii
Peniciliium camembertii
For resistance screening in plant breeding or fungicide testing Sclerotinia spp.
Fusarium
spp.
Typhula incarnata
Pseudocercosporella
spp.

Advantages of PROPHYTA’s Solid-State Fermentation Technology

  • Contamination-free growth conditions for long periods of time, which allows the production of even slow-growing fungi
  • Microprocessor-controlled fermentation with data collection
  • Cost effective
  • High production capacity after scale up